Monday, January 18, 2016

Science probes environmental autism link

In the 1980s, about one in 2,000 American kids was diagnosed with autism. Today the number is around one in 68, according to estimates from the U.S. Centers for Disease Control and Prevention’s Autism and Developmental Disabilities Monitoring Network.

This disconcerting increase has led to intensified examination into what environmental factors may play a role in the disorder’s development. A wide range of exposures have been scientifically linked to autism, including air pollutants, phthalates and other endocrine disruptors, pesticides such as Chlorpyrifos, and many more. Vaccines were considered a leading culprit, but more recent research has proven this connection wrong — although the subject still engenders much debate.

A 2014 study by researchers at the Harvard School of Public Health found a strong link between autism and in utero exposure to air pollution: The risk of autism was doubled among children of women exposed to high levels of particulate air pollution during pregnancy. Another 2014 study out of the University of California, Davis, determined that pregnant women living near fields and farms where chemical pesticides are applied experience a 66 percent increased risk of having a child with autism or a developmental delay.

The advocacy group Autism Speaks, which contributed to the funding of the Harvard study, believes that despite all the emerging data linking toxic exposures to autism, no environmental influence appears to cause or prevent autism by itself — rather, they appear to influence risk in those genetically predisposed to the disorder.

“It’s important to remember that not all mothers exposed to air pollution during pregnancy will have a child with autism, and not all children with autism were necessarily exposed to air pollution in utero,” said epidemiologist Michael Rosanoff, associate director for public health at Autism Speaks. “We know autism is a complex disorder, and underlying genetic and biological factors interact to influence susceptibility. The next step is to identify the biological mechanisms that connect air pollution to autism and identify ways to treat if not prevent the harm to brain development.”

While many studies linking environmental toxins and autism have been inconclusive, one developing research approach appears to hold great promise. Remarkably, fallen baby teeth can be used to track a child’s prenatal and infant exposure to chemicals — thus allowing scientists to determine what environmental causes may have contributed to the disorder’s development.

“As a result, we can use teeth like an archaeological record,” says Dr. Raymond Palmer of the University of Texas Health Science Center. “The enamel of different types of teeth begins to form at different points during prenatal development. In infancy, the enamel continues to absorb chemicals circulating through the baby’s body.”

Dr. Palmer says the greatest insights from dental analysis may come from looking at chemical exposures along with gene abnormalities, which may affect one’s vulnerability to potentially toxic chemicals.

Read the whole story at

No comments:

Post a Comment